Endometriosis Knowledgebase

PMID	15950672
Gene Name	CCR1
Condition	Endometriosis
Association	Associated
Sex	Female
Associated genes	CCR1
Other associated phenotypes	Endometriosis
Expression and regulation of CCR1 in peritoneal macrophages from women with and without endometriosis. Fertil Steril. 2005 Jun;83(6):1878-81. Wieser, Fritz\| Dogan, Songul\| Klingel, Karin\| Diedrich, Klaus\| Taylor, Robert N\| Hornung, Daniela Center for Reproductive Sciences, Department of Obstetrics and Gynecology, University of California, San Francisco, California, USA. CCR1 is a CC chemokine receptor with high affinity for RANTES (regulated upon activation, normal T cells expressed and secreted). CCR1 protein and mRNA concentrations in native peritoneal cells were twofold greater, in cultured peritoneal cells threefold greater, in patients with endometriosis compared to patients without endometriosis, as determined by Western blotting fluorescence activated cell sorting analysis, reverse transcription-polymerase chain reaction, and in situ hybridization. Mesh Terms: Analysis of Variance\| Cells, Cultured\| Endometriosis/genetics/metabolism\| Female\| Flow Cytometry\| Gene Expression Regulation/physiology\| Humans\| In Situ Hybridization\| Macrophages, Peritoneal/metabolism\| Receptors, CCR1\| Receptors, Chemokine/*